P2RX7

Across TCGA cell cohorts, P2RX7 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible P2RX7-associated genes across cancer lineages are OR9Q2, CLLU1-AS1, and GZMH. Each is linked with P2RX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX7-to-partner and partner-to-P2RX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9Q2 grouped by P2RX7-low versus P2RX7-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX7→partner) and Y-score (partner→P2RX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR9Q2 →	+0.015	+4.643	<.001	.004	3	1
LUNG_SCLC	CLLU1-AS1 →	+0.261	+4.044	<.001	.009	3	1
CNS	GZMH →	+0.040	+6.357	<.001	<.001	3	1
LARGE_INTESTINE	AGRP →	+0.130	+2.994	<.001	.006	3	1
LARGE_INTESTINE	PENK →	+0.440	+3.321	.001	.008	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR9Q2 by P2RX7 expression — LUNG_SCLC

Explore this box plot interactively →