P2RX6

Across TCGA cell cohorts, P2RX6 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible P2RX6-associated genes across cancer lineages are RXFP2, DEFA4, and OR6C70. Each is linked with P2RX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX6-to-partner and partner-to-P2RX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RXFP2 grouped by P2RX6-low versus P2RX6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX6→partner) and Y-score (partner→P2RX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RXFP2 →	+0.054	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	DEFA4 →	+0.019	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.292	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.003	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	C3orf84 →	+0.016	+4.681	<.001	.003	3	1
LARGE_INTESTINE	SH3GL2 →	+1.602	+3.474	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

RXFP2 by P2RX6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →