P2RX4

Across TCGA pan-cancer cohorts, P2RX4 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of P2RX4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where P2RX4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types P2RX4 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where P2RX4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RX4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.418	<.001	9	view →
CCRCC	All	II,III,IV	+0.409	<.001	9	view →
LSCC	Female	All	−0.687	<.001	8	view →
LUAD	All	All	+0.239	<.001	5	view →
HNSC	All	IV	+0.252	.015	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

P2RX4–COAD

Open the COAD breakdown →