Across TCGA cell cohorts, P2RX2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible P2RX2-associated genes across cancer lineages are DNAH8, GHRH, and COL6A5. Each is linked with P2RX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX2-to-partner and partner-to-P2RX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX2→partner) and Y-score (partner→P2RX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNAH8 →	+0.048	+4.237	<.001	.006	3	1
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
LARGE_INTESTINE	COL6A5 →	+0.509	+3.724	<.001	.004	3	1
LARGE_INTESTINE	TRARG1 →	+0.016	+3.023	.001	.002	3	1
LARGE_INTESTINE	CLPSL2 →	+0.577	+3.304	<.001	.008	3	1
LARGE_INTESTINE	DAZ4 →	+0.109	+2.977	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

P2RX2 survival (RNA) · tumor vs normal (RNA) · all P2RX2 data types