P2RX1

Across TCGA pan-cancer cohorts, P2RX1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated P2RX1 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher P2RX1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated P2RX1 expression acts as an unfavorable survival marker.

KIRP, UCEC, and SKCM are the cancer types where P2RX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.216	0.904	<.001	15	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	III,IV	0.256	0.707	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

P2RX1–KIRP (OS)

Open the KIRP breakdown →