P2RX1

Across TCGA pan-cancer cohorts, P2RX1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of P2RX1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where P2RX1 RNA is repressed in tumor relative to normal tissue. In most cancer types P2RX1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and LUAD are the cancer types where P2RX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−6.040	<.001	11	view →
COAD	Female	II,III,IV	−1.404	<.001	11	view →
LUAD	Male	All	−1.248	<.001	9	view →
LUSC	Female	All	−1.845	<.001	8	view →
KICH	Male	II,III,IV	−0.998	<.001	8	view →
UCEC	All	All	−1.386	<.001	6	view →
BRCA	All	II,III,IV	−0.375	<.001	6	view →
READ	All	All	−1.362	.002	5	view →
PRAD	All	All	−1.128	<.001	2	view →
HNSC	All	III,IV	+0.281	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

P2RX1–BLCA

Open the BLCA breakdown →