P2RX1

Across TCGA patient cohorts, P2RX1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RX1-associated genes across cancer lineages are p62 Lck ligand, PCNA, and S6_pS240_S244. Each is linked with P2RX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX1-to-partner and partner-to-P2RX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by P2RX1-low versus P2RX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX1→partner) and Y-score (partner→P2RX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.451	+2.817	<.001	.001	3	2
UCEC	PCNA →	+0.329	+3.700	<.001	.001	3	2
UCEC	S6_pS240_S244 →	+0.384	+3.183	.015	.009	3	2
UCEC	EGFR_pY1068 →	-0.246	-2.000	.012	.010	3	1
UCEC	eIF4E →	+0.169	+3.183	.041	.009	3	1
UCEC	ERK2 →	+0.183	+2.321	.015	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by P2RX1 expression — UCEC

Explore this box plot interactively →