P2RX1

Across TCGA cell cohorts, P2RX1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P2RX1-associated genes across cancer lineages are ADRA1A, C20orf85, and OR10K2. Each is linked with P2RX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX1-to-partner and partner-to-P2RX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRA1A grouped by P2RX1-low versus P2RX1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX1→partner) and Y-score (partner→P2RX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADRA1A →	+0.232	+4.705	<.001	.003	3	1
BLOOD_Leukemia	C20orf85 →	+0.042	+4.969	<.001	.003	3	1
BLOOD_Leukemia	OR10K2 →	+0.054	+4.705	<.001	.003	3	1
BLOOD_Leukemia	LCE5A →	+0.127	+4.152	.009	.009	3	1
BLOOD_Leukemia	OR10T2 →	+0.900	+4.276	<.001	.007	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.062	+4.539	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ADRA1A by P2RX1 expression — BLOOD_Leukemia

Explore this box plot interactively →