OVOL1

Across TCGA cell cohorts, OVOL1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. CNS shows the largest number of these associations.

The most reproducible OVOL1-associated genes across cancer lineages are TRIM42, WFDC10A, and PFN3. Each is linked with OVOL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OVOL1-to-partner and partner-to-OVOL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM42 grouped by OVOL1-low versus OVOL1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OVOL1→partner) and Y-score (partner→OVOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TRIM42 →	+0.004	+4.321	<.001	.009	3	1
CNS	WFDC10A →	+0.071	+4.315	.002	.006	3	1
CNS	PFN3 →	+0.058	+4.754	<.001	.005	3	1
CNS	IFNA4 →	+0.160	+4.321	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TRIM42 by OVOL1 expression — CNS

Explore this box plot interactively →