OTX2-AS1

Across TCGA pan-cancer cohorts, OTX2-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated OTX2-AS1 data layer compared with 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher OTX2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated OTX2-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and ESCA show a favorable association.

LUSC, KICH, and COAD are the cancer types where OTX2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.764	0.575	<.001	73	view →
KICH	OS	Tertile	III,IV	0.178	0.761	.001	57	view →
COAD	DFS	Tertile	All	0.512	0.723	.001	54	view →
DLBC	DFS	Tertile	IV	0.184	0.834	.004	39	view →
CHOL	OS	Quartile	All	0.381	0.922	.001	37	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	36	view →
UCEC	DFS	Quartile	IV	1.000	0.390	.028	32	view →
LIHC	OS	Quartile	III,IV	0.166	0.574	.003	24	view →
UVM	OS	Tertile	III,IV	0.353	1.000	.022	18	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	18	view →
STAD	OS	Median	All	0.256	0.476	.017	15	view →
THYM	OS	Quartile	All	0.850	1.000	.020	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

OTX2-AS1–LUSC (OS)

Open the LUSC breakdown →