OTX2-AS1

Across TCGA pan-cancer cohorts, OTX2-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OTX2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where OTX2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OTX2-AS1 is over-expressed in tumor.

KIRP, LUSC, and LIHC are the cancer types where OTX2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTX2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.017	.020	4	view →
LUSC	All	All	+0.113	<.001	3	view →
LIHC	All	All	+0.013	.013	2	view →
CHOL	All	All	+0.023	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

OTX2-AS1–KIRP

Open the KIRP breakdown →