OTULIN

Across TCGA patient cohorts, OTULIN RNA expression is significantly associated with the protein abundance of many other proteins, with 11,425 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible OTULIN-associated proteins across cancer lineages are NSUN2, TARS1, and TRIP13. Each is linked with OTULIN in more than 6 cancer types. Because this analysis shows association rather than direction, both OTULIN-to-partner and partner-to-OTULIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OTULIN versus NSUN2 in HNSC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (OTULIN→partner) and Y-score (partner→OTULIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NSUN2 →	+0.471	+0.963	<.001	<.001	3	7
LUAD	TARS1 →	+0.394	+0.483	<.001	<.001	3	6
LUAD	TRIP13 →	+0.702	+0.317	<.001	<.001	3	6
BRCA	PLOD3 →	+0.430	+0.393	.001	<.001	3	5
LSCC	WDR70 →	+0.267	+0.344	<.001	<.001	3	5
LUAD	GOLPH3 →	+0.309	+0.512	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,425 associations by consensus.

OTULIN vs NSUN2 — HNSC

Explore this scatter interactively →