OTUD7B

Across TCGA cell cohorts, OTUD7B mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTUD7B-associated genes across cancer lineages are GALP, MINDY4B, and TMEM114. Each is linked with OTUD7B in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUD7B-to-partner and partner-to-OTUD7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALP grouped by OTUD7B-low versus OTUD7B-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD7B→partner) and Y-score (partner→OTUD7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GALP →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MINDY4B →	+0.060	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TMEM114 →	+0.096	+4.643	<.001	.008	3	1
URINARY_TRACT	IL17F →	+0.056	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.053	+6.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

GALP by OTUD7B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →