OTUD6B

Across TCGA patient cohorts, OTUD6B mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD6B-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Heregulin, and Akt_pT308. Each is linked with OTUD6B in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUD6B-to-partner and partner-to-OTUD6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by OTUD6B-low versus OTUD6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD6B→partner) and Y-score (partner→OTUD6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.567	+3.009	.011	.019	3	1
UCEC	Heregulin →	-0.183	-3.000	.004	.036	3	1
UCEC	Akt_pT308 →	+0.653	+2.999	.047	.035	3	1
UCEC	Annexin-1 →	+0.654	+3.019	.017	.019	3	1
UCEC	Tuberin →	+0.364	+3.009	.010	.019	3	1
UCEC	CD20 →	-0.183	-3.321	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GSK-3a-b_pS21_S9 by OTUD6B expression — UCEC

Explore this box plot interactively →