OTUD6B

Across TCGA cell cohorts, OTUD6B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,463 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible OTUD6B-associated GO terms across cancer lineages are Positive regulation of DNA-directed DNA polymerase activity, Protein localization to chromosome, and Positive regulation of sister chromatid cohesion. Each is linked with OTUD6B in more than 16 cancer types. Because this analysis shows association rather than direction, both OTUD6B-to-partner and partner-to-OTUD6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-directed DNA polymerase activity grouped by OTUD6B-low versus OTUD6B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD6B→partner) and Y-score (partner→OTUD6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA-directed DNA polymerase activity →	+0.144	+0.612	.003	.001	3	17
BONE	Protein localization to chromosome →	+0.133	+0.760	.001	.006	3	16
BONE	Positive regulation of sister chromatid cohesion →	+0.095	+0.583	.003	.002	3	16
BONE	Replication fork processing →	+0.142	+0.934	.003	.005	3	15
UPPER_AERODIGESTIVE_TRACT	Interstrand cross-link repair →	+0.069	+1.114	.006	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.128	+1.375	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,463 associations by consensus.

Positive regulation of DNA-directed DNA polymerase activity by OTUD6B expression — BONE

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