OTUD6B-AS1

Across TCGA pan-cancer cohorts, OTUD6B-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of OTUD6B-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OTUD6B-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types OTUD6B-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where OTUD6B-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTUD6B-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.281	<.001	11	view →
LIHC	Male	II,III,IV	+1.169	<.001	9	view →
HNSC	Female	III,IV	+0.746	.008	8	view →
KIRC	All	All	−0.287	.001	6	view →
CHOL	All	II,III,IV	+1.305	<.001	5	view →
KIRP	Male	All	−0.547	<.001	5	view →
LUSC	All	III,IV	−0.638	.005	2	view →
UCEC	All	All	−0.576	.005	2	view →
LUAD	Female	All	−0.247	.013	2	view →
BLCA	Male	IV	−0.620	.007	1	view →
STAD	All	All	+0.383	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

OTUD6B-AS1–THCA

Open the THCA breakdown →