Across TCGA pan-cancer cohorts, OTUD6A Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated OTUD6A data layer compared with 16 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher OTUD6A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OTUD6A expression acts as an unfavorable survival marker.

LUSC and UCEC are the cancer types where OTUD6A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.224	0.764	<.001	36	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: OTUD6A tumor-vs-normal RNA expression · all OTUD6A data types