Across TCGA pan-cancer cohorts, OTUD6A RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OTUD6A’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where OTUD6A RNA is repressed in tumor relative to normal tissue. In most cancer types OTUD6A is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, LIHC, and KICH are the cancer types where OTUD6A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTUD6A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.009	.012	4	view →
LIHC	All	All	+0.007	.020	2	view →
KICH	Female	All	−0.015	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: OTUD6A RNA expression & survival · all OTUD6A data types