Across TCGA patient cohorts, OTUD6A mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD6A-associated genes across cancer lineages are 4E-BP1, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with OTUD6A in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUD6A-to-partner and partner-to-OTUD6A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD6A→partner) and Y-score (partner→OTUD6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.291	+3.467	.003	.002	3	2
COAD	Caspase-7-cleavedD198 →	+1.014	+3.467	.004	.002	3	1
UCEC	14-3-3_beta →	-0.075	-1.847	.037	.049	3	1
UCEC	EGFR_pY1068 →	-0.209	-1.807	.020	.025	3	1
UCEC	ACC_pS79 →	+0.370	+1.925	.003	.005	3	1
UCEC	GATA6 →	-0.124	-1.407	.032	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

OTUD6A survival (RNA) · tumor vs normal (RNA) · all OTUD6A data types