OTUD4

Across TCGA pan-cancer cohorts, OTUD4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated OTUD4 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher OTUD4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OTUD4 expression acts as an unfavorable survival marker, although some lineages such as OV and UCEC show a favorable association.

LSCC, PDAC, and GBM are the cancer types where OTUD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.444	0.837	.001	49	view →
PDAC	OS	Tertile	II,III,IV	0.392	0.676	<.001	30	view →
GBM	DFS	Tertile	All	0.621	0.895	.001	10	view →
OV	DFS	Median	All	0.923	0.660	.036	8	view →
UCEC	OS	Median	II,III,IV	1.000	0.653	.020	8	view →
LUAD	OS	Median	III,IV	1.000	0.663	.007	6	view →
HNSC	DFS	Median	IV	1.000	0.927	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OTUD4–LSCC (DFS)

Open the LSCC breakdown →