OTUD4

Across TCGA pan-cancer cohorts, OTUD4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of OTUD4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OTUD4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OTUD4 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, STAD, and THCA are the cancer types where OTUD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTUD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.549	<.001	6	view →
STAD	Male	II,III,IV	+0.993	.010	5	view →
THCA	All	All	−0.461	<.001	5	view →
CHOL	All	All	+1.067	<.001	2	view →
ESCA	Female	All	+1.050	.015	2	view →
UCEC	All	All	−0.603	.001	2	view →
KICH	All	All	−0.470	.004	2	view →
BRCA	All	III,IV	−0.358	.023	2	view →
COAD	Male	All	+0.325	.028	1	view →
LUSC	All	All	−0.237	.031	1	view →
KIRC	All	All	+0.193	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

OTUD4–HNSC

Open the HNSC breakdown →