OTUD4

Across TCGA patient cohorts, OTUD4 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD4-associated genes across cancer lineages are ASNS, ATM, and eIF4E. Each is linked with OTUD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both OTUD4-to-partner and partner-to-OTUD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by OTUD4-low versus OTUD4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD4→partner) and Y-score (partner→OTUD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.864	+3.008	<.001	.019	3	4
UCEC	ATM →	-0.542	-1.887	<.001	<.001	3	3
UCEC	eIF4E →	+0.145	+1.710	.009	<.001	3	2
UCEC	INPP4B →	-0.195	-1.716	.023	.002	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.331	-1.201	.005	.025	3	2
UCEC	p62 Lck ligand →	+0.271	+1.948	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ASNS by OTUD4 expression — COAD

Explore this box plot interactively →