OTUD4

Across TCGA cell cohorts, OTUD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,519 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OTUD4-associated GO terms across cancer lineages are DNA alkylation repair, Positive regulation of mRNA catabolic process, and Anaphase-promoting complex-dependent catabolic process. Each is linked with OTUD4 in more than 19 cancer types. Because this analysis shows association rather than direction, both OTUD4-to-partner and partner-to-OTUD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA alkylation repair grouped by OTUD4-low versus OTUD4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD4→partner) and Y-score (partner→OTUD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA alkylation repair →	+0.125	+0.842	<.001	<.001	3	20
SOFT_TISSUE	Positive regulation of mRNA catabolic process →	+0.058	+0.825	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Anaphase-promoting complex-dependent catabolic process →	+0.093	+0.850	.001	<.001	3	16
LUNG_SCLC	mRNA destabilization →	+0.064	+0.705	<.001	<.001	3	16
LUNG_NSCLC_LUAD	Protein branched polyubiquitination →	+0.100	+0.556	<.001	.002	3	16
STOMACH	Negative regulation of gene expression, epigenetic →	+0.065	+0.743	<.001	.002	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,519 associations by consensus.

DNA alkylation repair by OTUD4 expression — SOFT_TISSUE

Explore this box plot interactively →