OTUD4

Across TCGA cell cohorts, OTUD4 mutation is significantly associated with the RNA expression of many other genes, with 314 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTUD4-associated genes across cancer lineages are ODF4, KRTAP9-9, and OR6V1. Each is linked with OTUD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUD4-to-partner and partner-to-OTUD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF4 grouped by OTUD4-low versus OTUD4-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD4→partner) and Y-score (partner→OTUD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ODF4 →	+0.030	+5.000	<.001	.005	3	1
KIDNEY	KRTAP9-9 →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	OR6V1 →	+0.023	+5.000	<.001	.005	3	1
BLOOD_Lymphoma	METTL21C →	+0.019	+4.714	.004	.002	3	1
BLOOD_Lymphoma	OR8B12 →	+0.105	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	OR8D1 →	+0.034	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 314 associations by consensus.

ODF4 by OTUD4 expression — KIDNEY

Explore this box plot interactively →