OTUD3

Across TCGA patient cohorts, OTUD3 mutation is significantly associated with the RNA expression of many other genes, with 2,578 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD3-associated genes across cancer lineages are RNA5SP73, RPS10-NUDT3, and SRXN1. Each is linked with OTUD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUD3-to-partner and partner-to-OTUD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP73 grouped by OTUD3-low versus OTUD3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD3→partner) and Y-score (partner→OTUD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP73 →	+0.611	+6.837	<.001	<.001	3	2
UCEC	RPS10-NUDT3 →	+0.295	+2.894	<.001	.003	3	1
UCEC	SRXN1 →	+0.700	+3.343	<.001	.005	3	1
UCEC	POM121C →	+0.568	+3.483	<.001	.002	3	1
UCEC	WASL-DT →	+0.495	+3.218	.003	.009	3	1
UCEC	DCP1A →	+0.679	+2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,578 associations by consensus.

RNA5SP73 by OTUD3 expression — CESC

Explore this box plot interactively →