OTUD3

Across TCGA pan-cancer cohorts, OTUD3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of OTUD3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where OTUD3 RNA is repressed in tumor relative to normal tissue. In most cancer types OTUD3 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LIHC, and BRCA are the cancer types where OTUD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTUD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.711	<.001	7	view →
LIHC	All	II,III,IV	+0.576	<.001	7	view →
BRCA	All	III,IV	−0.640	<.001	6	view →
COAD	All	II,III,IV	+0.440	<.001	6	view →
STAD	Male	II,III,IV	+1.001	.004	5	view →
CHOL	Male	All	+1.683	<.001	3	view →
READ	Female	All	+0.802	.021	1	view →
KIRC	Female	All	+0.484	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

OTUD3–KICH

Open the KICH breakdown →