OTUD3

Across TCGA patient cohorts, OTUD3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD3-associated genes across cancer lineages are Notch1, c-Met_pY1235, and MEK1. Each is linked with OTUD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUD3-to-partner and partner-to-OTUD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by OTUD3-low versus OTUD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD3→partner) and Y-score (partner→OTUD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.234	+3.013	<.001	.018	3	2
UCEC	c-Met_pY1235 →	+0.082	+2.331	.017	.019	3	2
UCEC	MEK1 →	+0.580	+3.321	<.001	.010	2	2
UCEC	PCNA →	+0.294	+2.999	.003	.035	3	1
UCEC	PDCD4 →	-0.722	-3.321	<.001	.009	3	1
UCEC	STAT3_pY705 →	-0.532	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Notch1 by OTUD3 expression — UCEC

Explore this box plot interactively →