OTUB2

Across TCGA patient cohorts, OTUB2 mutation is significantly associated with the RNA expression of many other genes, with 1,417 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUB2-associated genes across cancer lineages are BPNT2P, MIR1266, and MTATP6P21. Each is linked with OTUB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUB2-to-partner and partner-to-OTUB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPNT2P grouped by OTUB2-low versus OTUB2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUB2→partner) and Y-score (partner→OTUB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BPNT2P →	+0.144	+4.661	<.001	.004	3	2
UCEC	MIR1266 →	+0.156	+2.864	.009	.003	3	2
UCEC	MTATP6P21 →	+0.204	+2.189	.001	.002	3	2
UCEC	RNU7-12P →	+0.289	+2.192	.004	.008	3	2
UCEC	RN7SL248P →	+0.066	+3.307	<.001	.003	3	2
SKCM	MIR7845 →	+0.499	+5.034	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,417 associations by consensus.

BPNT2P by OTUB2 expression — SKCM

Explore this box plot interactively →