OTOP3

Across TCGA patient cohorts, OTOP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,173 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible OTOP3-associated GO terms across cancer lineages are Ammonium homeostasis, Sister chromatid cohesion, and Regulation of keratinocyte proliferation. Each is linked with OTOP3 in more than 7 cancer types. Because this analysis shows association rather than direction, both OTOP3-to-partner and partner-to-OTOP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ammonium homeostasis grouped by OTOP3-low versus OTOP3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP3→partner) and Y-score (partner→OTOP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Ammonium homeostasis →	+0.494	+0.679	<.001	<.001	3	7
LAML	Sister chromatid cohesion →	+0.050	+0.045	<.001	<.001	3	7
STAD	Regulation of keratinocyte proliferation →	+0.044	+0.416	<.001	.001	3	7
ESCA	Epidermal cell differentiation →	+0.053	+1.442	<.001	<.001	3	7
LAML	Cytoskeleton-dependent cytokinesis →	+0.040	+0.045	<.001	<.001	3	7
ESCA	Intermediate filament organization →	+0.107	+1.444	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,173 associations by consensus.

Ammonium homeostasis by OTOP3 expression — STAD

Explore this box plot interactively →