OTOP3

Across TCGA pan-cancer cohorts, OTOP3 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated OTOP3 data layer compared with 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher OTOP3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OTOP3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUSC show a favorable association.

UCEC, SKCM, and HNSC are the cancer types where OTOP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.489	0.727	<.001	88	view →
SKCM	OS	Tertile	All	0.679	0.812	<.001	68	view →
HNSC	OS	Quartile	IV	0.802	0.560	<.001	52	view →
LUSC	OS	Tertile	II,III,IV	0.720	0.266	<.001	47	view →
THYM	DFS	Tertile	All	0.115	0.827	<.001	39	view →
SCLC	OS	Median	All	0.531	0.205	.001	36	view →
COAD	DFS	Tertile	II,III,IV	0.639	0.784	.010	18	view →
THCA	DFS	Tertile	IV	0.146	0.795	.004	18	view →
CHOL	OS	Tertile	II,III,IV	0.919	0.353	.009	18	view →
CESC	DFS	Median	All	0.632	0.403	.006	14	view →
KIRC	DFS	Tertile	All	0.761	0.883	.032	12	view →
PAAD	DFS	Tertile	All	0.499	0.317	.035	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

OTOP3–UCEC (OS)

Open the UCEC breakdown →