OTOP3

Across TCGA patient cohorts, OTOP3 mutation is significantly associated with the RNA expression of many other genes, with 860 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOP3-associated genes across cancer lineages are NFYAP1, LACTB, and LRRC59. Each is linked with OTOP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OTOP3-to-partner and partner-to-OTOP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFYAP1 grouped by OTOP3-low versus OTOP3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP3→partner) and Y-score (partner→OTOP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NFYAP1 →	+0.246	+5.010	<.001	.009	3	3
UCEC	LACTB →	+0.493	+2.732	.001	.003	3	3
UCEC	LRRC59 →	+0.573	+2.265	<.001	.005	3	3
UCEC	CCNA2 →	+0.725	+2.425	.005	.002	3	3
UCEC	GFI1 →	+0.586	+3.584	<.001	.002	3	2
UCEC	SFXN1 →	+0.466	+2.415	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 860 associations by consensus.

NFYAP1 by OTOP3 expression — CESC

Explore this box plot interactively →