OTOP3

Across TCGA cell cohorts, OTOP3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OTOP3-associated genes across cancer lineages are OCM2, OR14C36, and CCDC60. Each is linked with OTOP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOP3-to-partner and partner-to-OTOP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OCM2 grouped by OTOP3-low versus OTOP3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP3→partner) and Y-score (partner→OTOP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OCM2 →	+0.033	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR14C36 →	+0.015	+5.266	<.001	.001	3	1
OVARY	CCDC60 →	+0.064	+4.228	<.001	.006	3	1
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
LARGE_INTESTINE	TPD52L3 →	+0.044	+3.684	<.001	.006	3	1
SKIN	KRTAP21-1 →	+0.030	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OCM2 by OTOP3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →