OTOP1

Across TCGA patient cohorts, OTOP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,266 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible OTOP1-associated GO terms across cancer lineages are Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), DNA replication, and RNA capping. Each is linked with OTOP1 in more than 11 cancer types. Because this analysis shows association rather than direction, both OTOP1-to-partner and partner-to-OTOP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by OTOP1-low versus OTOP1-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP1→partner) and Y-score (partner→OTOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.045	+0.116	.003	.001	3	11
STAD	DNA replication →	+0.081	+0.149	<.001	<.001	2	12
TGCT	RNA capping →	+0.028	+0.077	<.001	<.001	3	11
STAD	Chromosome localization →	+0.058	+0.157	<.001	<.001	3	10
STAD	Metaphase chromosome alignment →	+0.061	+0.147	<.001	<.001	3	10
LIHC	Positive regulation of cell cycle process →	+0.031	+0.025	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,266 associations by consensus.

Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by OTOP1 expression — UCS

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