OTOP1

Across TCGA patient cohorts, OTOP1 protein abundance is significantly associated with the RNA expression of many other genes, with 586 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible OTOP1-associated genes across cancer lineages are PLS3, GABRE, and DNAJA3. Each is linked with OTOP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOP1-to-partner and partner-to-OTOP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OTOP1 versus PLS3 in LUAD, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP1→partner) and Y-score (partner→OTOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLS3 →	+0.942	+0.699	.002	.006	3	1
LUAD	GABRE →	+0.848	+0.490	.001	.007	3	1
LUAD	DNAJA3 →	+0.228	+0.580	.003	.001	3	1
LUAD	EIF3E →	+0.354	+0.598	.002	<.001	3	1
LUAD	GSDMD →	+0.541	+0.866	<.001	.001	3	1
LUAD	PYCR3 →	+0.488	+0.730	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 586 associations by consensus.

OTOP1 vs PLS3 — LUAD

Explore this scatter interactively →