OTOP1

Across TCGA cell cohorts, OTOP1 RNA expression is significantly associated with the mutation status of many other genes, with 96 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTOP1-associated genes across cancer lineages are IGSF22, NALCN, and ADAM15. Each is linked with OTOP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOP1-to-partner and partner-to-OTOP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGSF22 grouped by OTOP1-low versus OTOP1-high in URINARY_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP1→partner) and Y-score (partner→OTOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IGSF22 →	+4.087	+0.157	.009	.001	3	2
LUNG_NSCLC_LUAD	NALCN →	+2.700	+0.009	<.001	.001	3	2
LUNG_NSCLC_LUAD	ADAM15 →	+3.215	+0.011	.007	.003	3	2
LUNG_NSCLC_LUAD	ZNF609 →	+3.215	+0.011	.007	.003	3	2
KIDNEY	TSC2 →	+4.491	+0.011	.002	.002	3	1
BLOOD_Lymphoma	RIF1 →	+3.584	+0.004	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

IGSF22 by OTOP1 expression — URINARY_TRACT

Explore this box plot interactively →