OTOL1

Across TCGA patient cohorts, OTOL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,476 significant associations in total. STAD shows the largest number of these associations.

The most reproducible OTOL1-associated GO terms across cancer lineages are Regulation of protein serine/threonine kinase activity, Phospholipid biosynthetic process, and Establishment of protein localization to membrane. Each is linked with OTOL1 in more than 8 cancer types. Because this analysis shows association rather than direction, both OTOL1-to-partner and partner-to-OTOL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein serine/threonine kinase activity grouped by OTOL1-low versus OTOL1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOL1→partner) and Y-score (partner→OTOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of protein serine/threonine kinase activity →	+0.062	+0.102	<.001	<.001	3	9
STAD	Phospholipid biosynthetic process →	+0.069	+0.100	<.001	<.001	3	8
STAD	Establishment of protein localization to membrane →	+0.078	+0.100	<.001	<.001	3	8
STAD	Regulation of protein localization to plasma membrane →	+0.071	+0.104	<.001	<.001	3	8
STAD	Establishment or maintenance of cell polarity →	+0.067	+0.107	<.001	<.001	3	8
STAD	Regulation of protein secretion →	+0.048	+0.113	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,476 associations by consensus.

Regulation of protein serine/threonine kinase activity by OTOL1 expression — STAD

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