OTOL1

Across TCGA pan-cancer cohorts, OTOL1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated OTOL1 data layer compared with 5 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher OTOL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OTOL1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

THCA, LUSC, and READ are the cancer types where OTOL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	II,III,IV	0.548	0.952	<.001	120	view →
LUSC	DFS	Tertile	II,III,IV	0.266	0.622	.001	81	view →
READ	OS	Tertile	II,III,IV	0.111	0.919	<.001	63	view →
KIRP	OS	Tertile	II,III,IV	0.420	0.791	.009	51	view →
ESCA	OS	Tertile	II,III,IV	0.550	0.747	.008	28	view →
PAAD	OS	Tertile	II,III,IV	0.163	0.556	<.001	18	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
UCEC	DFS	Tertile	All	0.775	0.903	.008	18	view →
BLCA	OS	Tertile	II,III,IV	0.762	0.590	.040	12	view →
CHOL	OS	Tertile	All	0.168	0.624	.019	9	view →
SARC	OS	Tertile	All	0.718	0.884	.009	9	view →
SKCM	DFS	Quartile	All	0.700	0.577	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

OTOL1–THCA (OS)

Open the THCA breakdown →