OTOL1

Across TCGA patient cohorts, OTOL1 mutation is significantly associated with the RNA expression of many other genes, with 2,659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOL1-associated genes across cancer lineages are CHCHD4, SARS1, and RN7SKP265. Each is linked with OTOL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OTOL1-to-partner and partner-to-OTOL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD4 grouped by OTOL1-low versus OTOL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOL1→partner) and Y-score (partner→OTOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHCHD4 →	+0.382	+2.191	.002	.002	3	3
UCEC	SARS1 →	+0.488	+2.202	<.001	.001	3	3
HNSC	RN7SKP265 →	+0.677	+5.069	<.001	.008	3	3
HNSC	RN7SKP229 →	+0.248	+6.339	<.001	.001	3	3
UCEC	CIDECP1 →	+0.491	+2.716	<.001	<.001	3	3
UCEC	C6orf226 →	+0.541	+2.711	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,659 associations by consensus.

CHCHD4 by OTOL1 expression — UCEC

Explore this box plot interactively →