OTOL1

Across TCGA patient cohorts, OTOL1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOL1-associated genes across cancer lineages are Cyclin-B1, GAPDH, and Fibronectin. Each is linked with OTOL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both OTOL1-to-partner and partner-to-OTOL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by OTOL1-low versus OTOL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOL1→partner) and Y-score (partner→OTOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.930	+3.008	<.001	.019	1	4
SKCM	GAPDH →	+0.419	+2.459	.042	.018	3	2
UCEC	Fibronectin →	-0.336	-2.312	.019	.034	3	1
UCEC	FOXO3a →	+0.124	+2.128	.005	.010	3	1
UCEC	JNK2 →	+0.179	+2.834	.039	.034	3	1
UCEC	Ku80 →	+0.251	+3.013	.015	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Cyclin-B1 by OTOL1 expression — COAD

Explore this box plot interactively →