OTOL1

Across TCGA cell cohorts, OTOL1 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OTOL1-associated genes across cancer lineages are KRT36, IFNA21, and GABRA6. Each is linked with OTOL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOL1-to-partner and partner-to-OTOL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT36 grouped by OTOL1-low versus OTOL1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOL1→partner) and Y-score (partner→OTOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRT36 →	+0.069	+3.450	<.001	.007	3	1
LUNG_NSCLC_LUAD	IFNA21 →	+0.032	+3.374	<.001	.002	3	1
LUNG_NSCLC_LUAD	GABRA6 →	+0.046	+3.189	<.001	.007	3	1
LUNG_NSCLC_LUAD	SLC22A8 →	+0.025	+3.043	<.001	.006	3	1
LUNG_NSCLC_LUAD	OTOP1 →	+0.010	+3.536	.002	.001	3	1
LUNG_NSCLC_LUAD	OR10A4 →	+0.026	+3.695	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

KRT36 by OTOL1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →