Across TCGA patient cohorts, OTOG mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOG-associated genes across cancer lineages are ATM, MEK1, and 14-3-3_beta. Each is linked with OTOG in more than 2 cancer types. Because this analysis shows association rather than direction, both OTOG-to-partner and partner-to-OTOG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOG→partner) and Y-score (partner→OTOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.451	-2.321	.007	.033	3	3
UCEC	MEK1 →	+0.336	+2.115	.019	.017	3	2
UCEC	14-3-3_beta →	-0.106	-1.979	.007	.030	3	1
UCEC	EGFR_pY1068 →	-0.308	-3.321	.001	.009	3	1
UCEC	A-Raf_pS299 →	-0.207	-3.906	<.001	<.001	3	1
UCEC	Gab2 →	+0.313	+2.584	.025	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

OTOG survival (RNA) · tumor vs normal (RNA) · all OTOG data types