Across TCGA pan-cancer cohorts, OTOG RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated OTOG data layer compared with 5 for mutation status.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher OTOG RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OTOG expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.
UCEC, KICH, and ACC are the cancer types where OTOG RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.