Across TCGA cell cohorts, OTOG mutation is significantly associated with the RNA expression of many other genes, with 1,887 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTOG-associated genes across cancer lineages are FAM229B, ZIC5, and GCNA. Each is linked with OTOG in more than 2 cancer types. Because this analysis shows association rather than direction, both OTOG-to-partner and partner-to-OTOG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOG→partner) and Y-score (partner→OTOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM229B →	+0.880	+3.502	.004	.001	3	3
STOMACH	ZIC5 →	+1.014	+3.392	<.001	.001	3	3
STOMACH	GCNA →	+0.450	+2.944	.001	.007	3	3
LARGE_INTESTINE	COPS4 →	+0.668	+2.290	<.001	<.001	3	3
LARGE_INTESTINE	SEC24D →	+0.907	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	MED17 →	+0.453	+1.545	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,887 associations by consensus.

Exploration

OTOG survival (RNA) · tumor vs normal (RNA) · all OTOG data types