OTOF

Across TCGA pan-cancer cohorts, OTOF Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated OTOF data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher OTOF Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OTOF expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, UCEC, and READ are the cancer types where OTOF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.958	0.820	.002	14	view →
READ	OS	Median	IV	0.111	0.893	<.001	12	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	8	view →
SKCM	OS	Median	II,III,IV	0.964	0.818	.005	8	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
BRCA	DFS	Median	II,III,IV	0.148	0.519	.028	4	view →
LGG	DFS	Median	All	0.174	0.731	<.001	3	view →
SARC	DFS	Median	All	0.109	0.632	.038	3	view →
SCLC	DFS	Median	All	0.227	0.507	.035	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LIHC	DFS	Median	II,III,IV	0.114	0.419	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

OTOF–THYM (OS)

Open the THYM breakdown →