OTOF

Across TCGA pan-cancer cohorts, OTOF RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of OTOF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OTOF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OTOF is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where OTOF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTOF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.189	<.001	11	view →
HNSC	All	II,III,IV	+0.232	.001	6	view →
KIRP	Male	All	+0.078	<.001	6	view →
BLCA	All	All	+0.678	.044	2	view →
STAD	Male	III,IV	+0.266	.045	1	view →
CHOL	All	All	+0.203	.032	1	view →
LIHC	Female	All	+0.109	.014	1	view →
THCA	All	All	−0.048	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

OTOF–KIRC

Open the KIRC breakdown →