OTOF

Across TCGA patient cohorts, OTOF RNA expression is significantly associated with the go_rna of many other GO terms, with 7,107 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible OTOF-associated GO terms across cancer lineages are RIG-I signaling pathway, Regulation of cell shape, and Regulation of leukocyte proliferation. Each is linked with OTOF in more than 22 cancer types. Because this analysis shows association rather than direction, both OTOF-to-partner and partner-to-OTOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIG-I signaling pathway grouped by OTOF-low versus OTOF-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOF→partner) and Y-score (partner→OTOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	RIG-I signaling pathway →	+0.080	+0.277	<.001	.005	3	23
STAD	Regulation of cell shape →	+0.048	+0.222	<.001	<.001	3	22
STAD	Regulation of leukocyte proliferation →	+0.062	+0.193	<.001	<.001	3	22
ESCA	Interferon-mediated signaling pathway →	+0.061	+0.336	<.001	<.001	3	22
ESCA	Response to interleukin-15 →	+0.091	+0.316	<.001	.001	2	22
STAD	Regulation of response to cytokine stimulus →	+0.038	+0.251	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,107 associations by consensus.

RIG-I signaling pathway by OTOF expression — CHOL

Explore this box plot interactively →