OTOF

Across TCGA patient cohorts, OTOF mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOF-associated genes across cancer lineages are MYH11, Cyclin-B1, and 4E-BP1. Each is linked with OTOF in more than 3 cancer types. Because this analysis shows association rather than direction, both OTOF-to-partner and partner-to-OTOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by OTOF-low versus OTOF-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOF→partner) and Y-score (partner→OTOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MYH11 →	-1.775	-2.321	.007	.034	3	4
UCEC	Cyclin-B1 →	+0.481	+2.247	<.001	.001	3	4
STAD	4E-BP1 →	+0.422	+2.321	.001	.034	3	4
UCEC	Caspase-7-cleavedD198 →	+0.434	+1.434	.004	.005	3	4
UCEC	CD31 →	-0.081	-1.142	.033	.048	3	4
LUSC	HSP70 →	-0.415	-2.078	.012	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

MYH11 by OTOF expression — STAD

Explore this box plot interactively →