OTOF

Across TCGA cell cohorts, OTOF RNA expression is significantly associated with the go_rna of many other GO terms, with 1,522 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible OTOF-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with OTOF in more than 8 cancer types. Because this analysis shows association rather than direction, both OTOF-to-partner and partner-to-OTOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by OTOF-low versus OTOF-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOF→partner) and Y-score (partner→OTOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of myoblast fusion →	+0.078	+0.185	.006	.008	3	9
BONE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.076	+0.186	.007	.007	3	8
BONE	Regulation of syncytium formation by plasma membrane fusion →	+0.072	+0.163	.004	.009	2	8
UPPER_AERODIGESTIVE_TRACT	Protein polyubiquitination →	+0.050	+0.034	<.001	<.001	3	7
LIVER	RNA catabolic process →	+0.050	+0.250	<.001	.008	3	7
BONE	Regulation of myoblast fusion →	+0.079	+0.203	.002	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,522 associations by consensus.

Negative regulation of myoblast fusion by OTOF expression — BONE

Explore this box plot interactively →