OTOF

Across TCGA cell cohorts, OTOF mutation is significantly associated with the RNA expression of many other genes, with 2,201 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTOF-associated genes across cancer lineages are DDHD1, NEK4, and NCOR1. Each is linked with OTOF in more than 2 cancer types. Because this analysis shows association rather than direction, both OTOF-to-partner and partner-to-OTOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDHD1 grouped by OTOF-low versus OTOF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOF→partner) and Y-score (partner→OTOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DDHD1 →	+0.821	+3.130	<.001	<.001	3	3
LARGE_INTESTINE	NEK4 →	+0.550	+2.584	.001	.002	3	3
LARGE_INTESTINE	NCOR1 →	+0.812	+2.179	.001	.001	3	3
LARGE_INTESTINE	PPP4R2 →	+0.619	+3.130	<.001	<.001	3	3
LARGE_INTESTINE	STX18 →	+0.308	+3.321	.003	.003	3	3
LARGE_INTESTINE	MTFP1 →	+0.495	+3.087	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,201 associations by consensus.

DDHD1 by OTOF expression — LARGE_INTESTINE

Explore this box plot interactively →