OTOA

Across TCGA pan-cancer cohorts, OTOA Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated OTOA data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher OTOA Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated OTOA expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

UCEC, LGG, and GBM are the cancer types where OTOA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.965	0.623	.010	16	view →
LGG	OS	Median	All	0.221	0.889	<.001	6	view →
GBM	OS	Median	All	0.176	0.423	.006	6	view →
LUSC	OS	Median	III,IV	0.126	0.664	.008	6	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	6	view →
SKCM	DFS	Median	III,IV	0.338	0.669	.008	6	view →
ESCA	DFS	Median	II,III,IV	0.149	0.522	.047	3	view →
SCLC	DFS	Median	All	0.904	0.590	.030	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

OTOA–UCEC (DFS)

Open the UCEC breakdown →